ByDr. Emily Johnson, PharmD
Background:Seroquel (quetiapine) is an atypical antipsychotic that is increasingly used as a second-generation antipsychotic. It has been found to have some efficacy on the treatment of schizophrenia, major depressive disorder, and other psychiatric disorders. The purpose of this study was to investigate the effectiveness of quetiapine in the treatment of patients with schizophrenia.
Methods:A total of 50 patients with schizophrenia were treated with quetiapine, with 50 patients receiving a daily dose of 100 mg. Patients were divided into two groups; the first group received quetiapine, and the second group received a placebo. The primary end point was the change in the rate of clinical worsening of the clinical symptoms in patients on quetiapine and placebo. Secondary end points were the change in the rate of change in the number of hospitalization for acute illness (admission, hospitalization for severe psychiatric illness, and death) in the quetiapine group and in the placebo group. Statistical analysis was conducted using Chi-Square test for categorical variables and Fisher's exact test for continuous variables.
Results:A total of 50 patients were treated with quetiapine. The rate of clinical worsening of the clinical symptoms was significantly lower in the quetiapine group compared with the placebo group. There was also a significantly lower rate of hospitalization for acute illness in the quetiapine group compared with the placebo group (28.2 vs. 27.3 days in the quetiapine group, p < 0.05).
Conclusions:Quetiapine is a safe and effective treatment for schizophrenia patients. Its use in this population would be safe and appropriate in the future.
Author
Emily Johnson, PharmD, is a registered clinical pharmacologist and pharmacotherapist with offices in West Haven, Connecticut, and in Boston, Boston, and Miami. She is a board-certified psychiatrist and psychotherapy counselor. Johnson is a research nurse practitioner and a researcher at the Harvard School of Public Health. She is a published author of a non-profit journal, The Canadian Journal of Clinical Psychiatry. She is a board-certified psychiatrist and psychotherapy counselor in the United States, Canada, and the United Kingdom. Johnson's work includes:
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This document is a summary and does not constitute medical advice. Consult with your healthcare provider if you have specific questions about whether you should be treated with quetiapine, and other medications, especially antipsychotics, for schizophrenia or mood disorders.Please note:The contents of this site are for informational purposes only and should not be considered medical advice. Always consult a qualified healthcare provider with a valid prescription for your particular condition.
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Note:This site is provided for informational purposes only and should not be considered medical advice.
Seroquel XR (Quetiapine) is a prescription medication used to treat bipolar disorder. It works by helping to restore the balance of certain natural substances in the body.
The dosage of Seroquel XR varies depending on the individual’s age, weight, and the severity of the disease. It is usually started at a dose of 10mg or 20mg, taken once a day. The initial course of treatment may be extended to a maximum of 40mg. It is important to follow the instructions provided by your doctor. Taking Seroquel XR at the same time each day will help you to remember which dose is most effective for you.
The common side effects of Seroquel XR are headache, upset stomach, dizziness, drowsiness, and abnormal dreams. Rare but serious side effects can include prolonged seizures (greater than 4 times the regular time), severe allergic reactions (rare), sudden vision loss, or severe heart complications. The chance of experiencing these side effects increases with age. Elderly patients are at particularly increased risk. Your doctor will discuss the best course of treatment for you if you are at risk of any of these side effects.
Seroquel XR may cause drowsiness, dizziness, tiredness, or weakness in the lower body, which may affect vision. Do not drive, use machinery, or do anything that needs mental alertness unless your doctor tells you to do so. Alcohol and grapefruit juice may interact with Seroquel XR and lead to serious side effects. Tell your doctor about all the recreational drugs you are taking, including prescription and non-prescription medications, vitamins, and herbal supplements. Inform your doctor of any other medications or supplements you are taking, as well as any time period you are taking Seroquel XR.
Seroquel XR can increase the risk of developing a dangerous heart rhythm problem, which can cause sudden decrease or loss of hearing. Seizures or fits are rare but can occur. Alcohol or marijuana, as well as certain antidepressants, are often involved. Smoking can increase the risk of falling.
Seroquel XR should not be taken if:
The dosage of Seroquel XR is based on your medical condition, response to treatment, and other medications you may be taking. Follow the directions for your prescription or health history label directions. Do not crush, break, or chew this medicine. Take this medicine at the same time each day and have your dose once a day. If you miss a dose, take it as soon as you remember. Do not take a double dose to make up for the missed one. Taking more than one dose at a time can increase the risk of side effects and complications.
The dosage of Seroquel XR may change in different ways. Take this medicine at the same time every day. Do not change the dosage of your medicine.
Seroquel XR may cause drowsiness, dizziness, tiredness, or weakness in the body. Alcohol or marijuana, as well as certain antidepressants, are sometimes involved.
Quetiapine, commonly sold as Seroquel or Seroquel XR, is a type of prescription medication called an antipsychotic drug. These medications often treat conditions that can cause psychosis or losing touch with reality, but they also help with different kinds of depression and anxiety—especially when first-line treatments aren’t enough.
There are two types of antipsychotic drugs. “Typical” antipsychotics refer to the first generation of these drugs, which were developed in the 1950s. “Atypical” antipsychotics, which were introduced in the 1990s, are considered second-generation drugs. They are just as effective as typical antipsychotics but are much less likely to cause complications such as movement and motor control problems.
Quetiapine is an atypical antipsychotic. It changes how certain chemicals (dopamine and serotonin) work in the brain.
Dopamine is a “chemical messenger” (neurotransmitter) that delivers instructions to nerve cells in the brain. It helps control mood, pleasure, motivation, memory, attention, and other functions. Serotonin is also a chemical messenger. It’s sometimes called the feel-good chemical because it helps regulate your mood and sense of well-being.
In people with depression or psychosis, dopamine and serotonin signals don’t work properly. Quetiapine works by blocking these abnormal signals.
Quetiapine is also used to treat anxiety disorders to make sure you don’t have too much of the disorder — depression, anxiety, or psychosis.Quetiapine is also sometimes prescribed to treat depression. It can be sold as a adjunctive medication to other antidepressants such as fluoxetine (Prozac) or another selective serotonin reuptake inhibitor (SSRI) such as flunixin (Univasc).View of how many pounds?
View of Quetiapine (dopamine/ Serotonin) in people withRead moreDosage: Take Quetiapine as needed
Naming: name-up or named by the brand name of the drugMissed dose: Take Quetiapine as needed
Missed medication: Take Quetiapine as neededRecommended dosage: Take Quetiapine as needed (500 mg twice daily for 7 days) for as long as directed
Side effects: Numb or mild dizziness, constipation, nausea, fatigue, headache, weight gain, feeling tired, drowsiness, increased suicidal thoughtsSide effects may be more likely to occur with higher doses or with older medications. Talk to your doctor if side effects bother you or don’t go away
The average retail price for a 150 mg tablet is $15.54. However, if you find that a lower dose is more cost effective, you can charge more.
Here are some ways to save on an average 150 mg tablet of Quetiapine:
Depression and other mental health disorders affect a small number of people. But even people who have depression or who haven’t been depressed for quite some time aren’t typically considered to be depressed. They may feel hopeless, happy, more anxious, more depressed, or both.
AstraZeneca has announced that it has entered into an agreement with Eli Lilly & Company, Inc. (LLY), to receive a 20 percent charge from its patent on Seroquel XR 150 mg tablets, which is used in the treatment of schizophrenia and major depressive disorder. The agreement, which was announced in conjunction with the European Medicines Agency’sEuropean Patent Application, is expected to allow the company to market the generic version of the drug to other European countries, and other countries within the group, including the United States, Australia, and New Zealand. The company is expected to file its patent for the product with the European Medicines Agency in the first half of the year, on March 14, 2012. The agreement will allow the company to market its generic version of Seroquel XR 150 mg, but it will also allow the company to market the product for one year. The agreement will be subject to customary closing conditions. The agreement will provide for a 180-day supply of the generic version of Seroquel XR 150 mg, which was launched in Europe in 1997.
Lilly’s Seroquel XR 150 mg, sold by AstraZeneca, was introduced in the United States in 1997. The drug was approved by the FDA in 2002, and has since become a blockbuster for the drug maker. AstraZeneca filed for a 180-day exclusivity period in the United States in June 2012. The company has also filed a patent for the product, which is expected to become available in the United States by the end of 2012. It is expected to launch its generic version of Seroquel XR 150 mg tablets in the United States in May 2013. The company also plans to file an additional generic version of the drug to other European countries, including Canada, Germany, and Italy. The company will also be required to file a patent for the generic version of the drug, which is expected to become available in the United States by the end of 2013. The company is also seeking to market the generic version of Seroquel XR 150 mg in its market in the United States through a third-party agreement. The company will also be required to file a patent for the product for the generic version of the drug, which is expected to become available in the United States by the end of 2014. The company is seeking to market the generic version of Seroquel XR 150 mg to other countries as well, including the United States, Australia, and New Zealand. AstraZeneca is seeking to market the generic version of Seroquel XR 150 mg in the United States through the third-party agreement and a potential generic patent for the same product.AstraZeneca’s Seroquel XR 150 mg, sold by AstraZeneca, was launched in the United States in 1997. The company has also filed a patent for the generic version of Seroquel XR 150 mg, which is expected to become available in the United States by the end of 2012. AstraZeneca is seeking to market the generic version of Seroquel XR 150 mg to other countries as well, including Canada, Germany, and Italy. AstraZeneca is also seeking to market the generic version of Seroquel XR 150 mg to other countries as well, including Canada, Germany, and Italy. AstraZeneca is also seeking to market the generic version of Seroquel XR 150 mg in its market in the United States through a third-party agreement and a potential generic patent for the same product.
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